FIG. 3.

Virulence studies of A. pleuropneumoniae ΔhlyX in an aerosol infection model. Symbols: •, A. pleuropneumoniae AP76 wild-type strain (AP76); ▴, A. pleuropneumoniae ΔhlyX (ΔdmsA). The central symbol within the hourglass shape represents the geometric mean, the hinges present the values in the middle of each half of data, and the top and bottom symbols mark the maximum and minimum value. Asterisks denote statistical significance (P < 0.05) in the Wilcoxon signed-rank test. (A) Body temperatures of pigs over the course of 6 days, with day 0 marking the day of infection; (B) lung lesion scores assessed according to the method of Hannan et al. (14). Statistical significance (P < 0.05) in the Mann-Whitney Test is denoted by an asterisk.