FIG. 2.

C3H/HeJ mice exhibit rapid intestinal inflammation in response to acute E. histolytica challenge. (A) Histology 18 h after intracecal challenge with E. histolytica trophozoites showed diffuse cecal inflammation with submucosal edema (asterisk) in the susceptible C3H/HeJ strain compared with the normal histology in the C57BL/6 mouse (hematoxylin and eosin staining). Magnification, ×20. (B) Cross-sectional cecal thickness was measured in both strains at 18 h. The data are means and standard errors (n = 8). An asterisk indicates that the P value is 0.007.