FIG. 3.

Serum and lung soluble MIP-2 and IL-6 levels in C4 KO mice infected i.t. with serotype 8 pneumococcus: serum MIP-2 and IL-6 (A and B) and lung MIP-2 and IL-6 (C and D) protein levels as determined by ELISA in PBS-treated mice (open bars), IgM-treated mice (solid bars), and D11-treated mice (cross-hatched bars) at 6 and 24 h after infection. The bars indicate the means of three independent experiments, and the error bars indicate the standard errors of the means. An asterisk indicates that the P value is <0.05 for a comparison of the control mice to D11-treated mice at 24 h after infection, as determined by an unpaired t test; a plus sign indicates that the P value is <0.05 for a comparison of the levels at 6 h and 24 h after infection, as determined by an unpaired t test (n = 12 to 15 mice per time).