FIG. 1.

Proliferative responses of peripheral blood mononuclear cells from infected and healthy control cows stimulated in vitro with five M. avium subsp. paratuberculosis recombinant proteins. The results are expressed as a stimulation index, and the error bars represent standard deviations from the means. No significant proliferation was noted to any antigen by PBMCs from noninfected cows (P > 0.05). 85A and the 35-kDa protein showed the most proliferative activity in low and medium shedders, respectively.