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Immunogenicity of CRM197 after transcutaneous immunization. Groups of six mice were immunized by applying 20, 10, or 5 μg of CRM197, together with 20 μg of CT, onto tape-stripped skin (A), mildly ablated skin (B), or intact skin (C). Serum samples collected 2 weeks after the second boost were assayed by ELISA for the presence of anti-CRM197-specific antibodies. The results represent average antibody titers of six mice ± the SEM. The scale for panel C is the same as for panel B.
