Table 2. Optimization results of CAP-M using the design of experiments by RSM^a.

Run	Particle size (nm)	Entrapment efficiency (%)	Drug release after 4 h (%)
1	19.47 ± 1.43	89.3 ± 2.65	65.82 ± 4.53
2	25.89 ± 1.03	62.11 ± 3.22	60.36 ± 3.22
3	29.42 ± 0.53	56.2 ± 1.89	61.08 ± 2.64
4	17.81 ± 1.54	75.01 ± 4.53	66.52 ± 2.07
5	14.92 ± 2.03	87.97 ± 2.43	67.24 ± 3.04
6	23.82 ± 0.04	88.43 ± 2.11	64.07 ± 2.53
7	21.94 ± 0.42	85.24 ± 1.53	64.75 ± 1.53
8	22.69 ± 1.52	63.29 ± 1.11	62.48 ± 4.24
9	44.52 ± 1.68	28.19 ± 2.59	61.74 ± 2.67
10	35.41 ± 2.53	29.02 ± 2.31	58.94 ± 2.54
11	17.27 ± 2.11	76.92 ± 1.96	66.69 ± 3.25
12	42.08 ± 1.80	23.75 ± 1.04	55.45 ± 4.62
13	24.28 ± 0.98	55.45 ± 1.54	61.2 ± 2.34
14	17.35 ± 1.04	76.73 ± 2.45	66.87 ± 3.24
15	36.82 ± 1.66	32.93 ± 1.42	60.34 ± 2.89

^aValues are presented as means ± SD (n = 3).