FIG. 2.

Protocol used for infection of rabbit 2, which became severely ill on primary challenge with 5 × 10³ A. fumigatus conidia but which, after recovery, tolerated doses 10-fold and 100-fold higher when given 9 weeks after the first or 7 weeks after the second challenge. Data from monitoring body weight and body temperature have been plotted, with fever being reported when the body temperature rose above 39.5°C (dashed line), a temperature that is normal in healthy rabbits (3). The black horizontal bars at the top of the figure show times rabbits received cortisone and ceftazidime as described in Materials and Methods. The darker vertical bar for rabbit weight shows the weight at the time of challenge. Sera 2a and 2b are listed in Table 1.