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Experimental design for the study of cynomolgus monkeys as an NHP model for scrub typhus
| Animal ID | Phase I (week 0, infection)
|
Phase II (week 4, vaccination)
|
Phase III (week 8, challenge)
|
|||
|---|---|---|---|---|---|---|
| Dose (MuLD50) | Type | Dose (μg Kp r56) | Type | Dose (MuLD50) | Type | |
| 1 | 106 | Infection | 0 | Control | 106 | Challenge |
| 2 | 104 | Infection | ||||
| 3 | 102 | Infection | 0 | Control | 106 | Challenge |
| 4 | 101 | Infection | ||||
| 5 | 0 | Control | 850 | Vaccination | 106 | Challenge |
| 6 | 0 | Control | 850 | Vaccination | 106 | Challenge |
