Table 3.

Multiplicative interaction analysis

Variables	Age<60		Age>60		p for interaction	Multiplicative scale
	HR 95% CI	p value	HR 95% CI	p value
N(events)	454(73)		647(368)
Log-CALLY	0.28(0.16,0.48)	<0.001	0.70(0.55,0.88)	0.003	0.002
Subgroups
Log-CALLY<1.107	1(Reference)		1(Reference)
Log-CALLY>1.107	0.34(0.2,0.59)	<0.001	0.73(0.57,0.94)	0.015	0.009	1.99(1.18,3.37),p=0.01

Variables	Man		Female		p for interaction	Multiplicative scale
	HR 95% CI	p value	HR 95% CI	p value
N(events)	635(233)		466(208)
Log-CALLY	0.54(0.4,0.73)	<0.001	0.75(0.56,1.02)	0.067	0.038
Subgroups
Log-CALLY<1.107	1(Reference)		1(Reference)		0.033
Log-CALLY>1.107	0.56(0.4,0.73)	<0.001	0.82(0.6,1.12)	0.215		1.57(1.04,2.37),p=0.03

The interaction effects between the CALLY index, gender, and age were analyzed. A p-value of < 0.05 is considered statistically significant