TABLE 2.

Mean (Range) of Physical Chemical Properties of CNS and Non-CNS Drugs from Mahar Doan

Physical Chemical Properties	CNS	Non-CNS
Molecular weight	319 (151–655)	330 (163–671)
ClogP	3.43* (0.16–6.59)	2.78* (−2.81–6.09)
ClogD	2.08 (−1.34–6.57)	1.07 (−2.81–5.53)
PSA	40.5 (4.63–108)	56.1 (3.25–151)
Hydrogen bond donors	0.85* (0–3)	1.56* (0–6)
Hydrogen bond acceptors	3.56 (1–10)	4.51 (1–11)
Flexibility (rotatable bonds)	1.27* (0–5)	2.18* (0–4)
Aromatic rings	1.92 (0–4)	1.93 (0–4)

^*Statistically different.