TABLE 3.
Comparison of All Marketed Oral Drugs between 1983 and 2002 and CNS and Gastrointestinal-Metabolic Drugs According to Leeson
| Physical Chemical Properties | All Drugs* (n = 329) | CNS (n = 74) | GI/Metabolic (n = 38) |
|---|---|---|---|
| Molecular weight | 377 | 310 | 378 |
| ClogP | 2.50 | 2.50 | 1.90 |
| %PSA | 21.0 | 16.3 | 26.7 |
| (OH + NH) | 1.77 | 1.50 | 2.71 |
| (O + N) | 6.33 | 4.32 | 6.84 |
| Hydrogen bond acceptors | 3.74 | 2.12 | 4.34 |
| Rotatable bonds | 6.42 | 4.70 | 7.63 |
| Aromatic rings | 2.88 | 2.85 | 2.32 |
*
All drugs contains the 74 CNS drugs as part of the data set.