Table 3.

Risk of Stroke According to Fried Fish/Fish Sandwich Consumption^*

	Frequency of Fish Consumption
Stroke Risk	<1 Time/mo (n = 2302)	1–3 Times/mo (n = 1542)	≥1 Times/wk (n = 934)	Pfor Trend
Total stroke	(n = 288)	(n = 201)	(n = 137)
Age adjusted	1.0 (Referent)	1.13 (0.95–1.36)	1.34 (1.09–1.66)	.005
Model 1†	1.0 (Referent)	1.15 (0.95–1.39)	1.30 (1.04–1.61)	.02
Model 2‡	1.0 (Referent)	1.17 (0.97–1.42)	1.37 (1.09–1.73)	.006
Model 3§	1.0 (Referent)	1.14 (0.94–1.38)	1.33 (1.05–1.68)	.02
Ischemic stroke	(n = 243)	(n = 173)	(n = 121)
Age adjusted	1.0 (Referent)	1.16 (0.95–1.41)	1.43 (1.14–1.79)	.002
Model 1†	1.0 (Referent)	1.17 (0.96–1.43)	1.36 (1.08–1.72)	.008
Model 2‡	1.0 (Referent)	1.19 (0.97–1.46)	1.44 (1.12–1.85)	.003
Model 3§	1.0 (Referent)	1.15 (0.94–1.42)	1.39 (1.08–1.79)	.01
Hemorrhagic stroke	(n = 37)	(n = 22)	(n = 14)
Age adjusted	1.0 (Referent)	0.92 (0.54–1.57)	0.94 (0.90–1.76)	.81
Model 1†	1.0 (Referent)	0.92 (0.52–1.61)	0.98 (0.51–1.88)	.90
Model 2‡	1.0 (Referent)	0.96 (0.54–1.70)	1.06 (0.53–2.11)	.91
Model 3§	1.0 (Referent)	0.98 (0.55–1.74)	1.10 (0.55–2.19)	.84

^*Data are hazard ratios (95% confidence intervals) unless otherwise specified.

^†Adjusted for cardiovascular risk factors (age, sex, education, diabetes, prevalent coronary heart disease, smoking status, pack-years of smoking, and aspirin use).

^‡Further adjusted for other risks and lifestyle factors (body mass index, leisure-time physical activity, alcohol use, and total caloric intake).

^§Further adjusted for potential confounders/mediators (systolic blood pressure and low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, and C-reactive protein levels).