TABLE 2.

Relative Risk of CHD According to Both EPA + DHA and n-6 Polyunsaturated Fatty Acid Intake^*

	Low EPA + DHA		High EPA + DHA
	Low n-6 (n = 10 982)	High n-6 (n = 12 129)	Low n-6 (n = 11 880)	High n-6 (n = 10 731)
Sudden death, n	62	65	46	45
Age adjusted	1.0 (reference)	0.85 (0.60–1.20)	0.48 (0.32–0.71)	0.69 (0.48–1.01)
Multivariate	1.0 (reference)	0.76 (0.52–1.11)	0.52 (0.34–0.79)	0.60 (0.39–0.93)
Nonfatal MI, n	349	395	408	369
Age adjusted	1.0 (reference)	1.14 (0.99–1.32)	1.08 (0.94–1.25)	1.09 (0.94–1.27)
Multivariate	1.0 (reference)	1.09 (0.93–1.28)	1.16 (0.99–1.36)	1.09 (0.91–1.29)
Total CHD, n	549	576	617	564
Age adjusted	1.0 (reference)	1.01 (0.90–1.14)	0.96 (0.86–1.08)	1.02 (0.91–1.16)
Multivariate	1.0 (reference)	0.97 (0.85–1.10)	1.05 (0.92–1.19)	1.02 (0.89–1.16)

^*Grouped according to < or ≥ median intake of both n-6 fatty acids (11.2 g/d) and EPA + DHA (250 mg/d), with the reference group being men consuming < median intake of both. Values are hazard ratios (95% CI). Multivariate model is adjusted for age (5-year categories); body mass index (quintiles); smoking (5 categories); physical activity (quintiles); history of diabetes, hypertension, or hypercholesterolemia; aspirin use; alcohol use (quintiles); and intake of protein, saturated fat, dietary fiber, monounsaturated fat, trans fatty acids, total calories, and ALA (each in quintiles). Total CHD represents combined sudden death, other coronary heart disease deaths, and nonfatal MI.