Table 4.

Rank of conserved residues in the three families^a

S1-Chymotrypsin		S8-Subtilisin		C1-Papain
(A)1gct	(B) family	(C) 1svn	(D) family	(E)1huc	(F) family
HIS57, 0	SER195,0	ASP32, 0	SER221, 0.14	HIS199, 0	GLN23, 0.17
SER195, 0	ALA55, 0	HIS64, 0	MET222, 0.29	ASN219, 0	CYS29, 0.33
CYS42, 0	HIS57, 0.2	SER221, 0	HIS64, 0.43	GLN23, 0	SER28, 0.33
ALA55, 0	CYS42, 0.2	SER125, 0	SER125, 1.00	SER220, 0	SER220, 0.83
CYS58, 0	CYS58, 0.2	LEU96, 1	PRO225, 1.43	TRP221, 0	GLY27, 1.00
GLY196, 0	GLY196, 0.2	LEU126, 1	ASP32, 2.00	CYS29, 1	HIS199, 1.67
SER214, 1	SER214, 1.4	MET222, 1	ALA223, 2.14	SER28, 2	CYS26, 2.33
ASP102, 2	ASP102, 1.8	PRO225, 2	THR220, 2.57	GLY27, 3	TRP221, 2.5
GLY43, 3	GLY43, 2.2	ALA223, 3	ASN155, 3.29	CYS26, 4	CYS71, 2.83
ILE212, 3	ILE212, 3.0	THR220, 4	LEU126, 4.14	CYS71, 5	PHE32, 3.17
GLY197, 4	GLY197, 3.0	ASN155, 5	PHE189, 4.29	GLY73, 6	ASN219, 3.33
GLY140, 5	GLY140, 4.0	PHE189, 6	HIS226, 4.71	GLY70, 6	GLY73, 3.83
GLY193, 5	GLY193, 4.0	HIS226, 6	LEU96, 4.85	PHE32, 6	GLY70, 3.83
GLY44, 6	GLY44, 4.4	SER190, 7	SER190, 5.14	ILE201, 7	TRP30, 4.00
ALA56, 6	ASP194, 5.0	PRO201, 7	PRO201, 5.71	TRP30, 7	TYR94, 6.00
GLY142, 6	ALA56, 5.0	HIS67, 8	HIS67, 6.71	GLY229, 8	GLY229. 6.17
ASP194, 6	GLY142, 5.0	VAL177, 9	VAL177, 6.71	ILE203, 8	PRO76, 6.67
CYS191, 7	CYS191, 6.0	SER207, 9	SER207, 7.71	LEU216, 8	LEU216, 7.17
TRP141, 8	TRP141, 6.6	ALA228, 9	ALA228, 7.71	PRO76, 8	ALA31, 7.17
CYS182, 8	CYS182, 7.0	THR66, 10	ASP181, 8.29	TYR214, 8	TYR146, 7.17
ALA183, 8	ALA183, 7.0	ASP181, 10	THR66, 8.71	CYS62, 9	ILE201, 7.33
GLY211, 8	GLY211, 7.0	LEU233, 10	LEU233,17.71	ALA34, 9	ILE203, 7.67
				ALA31, 9	TYR214, 7.67
				SER152, 9	ALA34, 8.17
				TYR146, 9	SER152, 8.33
				TYR94, 9	CYS62, 8.67

^*Catalytic residues are written in italic and bold face. Numbers are the scores defined in Section 2.5.