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. 2025 Apr 9;15:1552937. doi: 10.3389/fonc.2025.1552937

Table 3.

Multivariate Cox regression analysis for early-stage IBC patients with HR+.

Factors Multivariate analysis
HR 95%CI P
Lower Upper
Ki67 <22.50% vs ≥22.50% 3.601 1.395 9.298 0.008
Chemotherapy No vs Yes 3.143 1.143 8.647 0.027
TOP2A <63.35% vs ≥63.35% 3.331 1.053 10.531 0.041
HER2 <65.25% vs ≥65.25% 7.501 2.674 21.036 0.000

IBC, invasive breast cancer; HR, hormonal receptor; HER2, human epidermal growth factor receptor 2; TOP2A, topoisomerase II alpha; HR, hazard ratio; CI, confidence interval. The bolded values present P<0.05.