Table 5.
Local control vs local failure at 12 months
| Variables | Local control (n = 44) | Local progression(n = 18) | HR (CI95%) | P |
|---|---|---|---|---|
| Age | 53Y | 53.5Y | 0.97 (0.74–2.1) | 0.87 |
| HER- 2 positive (yes) | 50% | 16.7% | 0.2 (0.05–0.79) | 0.015 |
| Liminal B (yes) | 21% | 5% | 0.14 | 0.049 |
| Size of tumor (> 5 cm) | 18.1% | 66.7% | 3.4 (2.5–7.6) | < 0.001 |
| PTV (CC) | 56.2 CC | 83.7 CC | 0.042 | |
|
Dose BED (α/β = 10) (median, range) |
42.5 Gy (37.5–59.5) |
37.5 Gy (30–48) |
0.008 | |
| BED > 40 Gy | 52.5% | 16.6% | 0.18 (0.049–0.79) | 0.015 |
| Inclusion of surgical corridor (Yes) | 13.6% | 38.3% | 4.03 (1.1–14.5) | 0.034 |
| Time from surgery to radiation (days median, range) |
26.9 days (18–42) |
32.5 days (16–44) |
0.009 | |
|
Time from surgery > 28 days |
38.6% | 77.8% | 5.5 (1.56–19.7) | 0.008 |
| En bloc resection | 88.6% | 83.3% | 1.6 (0.65–3.7) | 0.43 |
| Type of metastases (Cystic) | 20.4% | 55.5% | 4.8(1.4–15.8) | 0.009 |
| Location (cerebellum) | 6.8% | 27.7% | 5.2(1.1–25.4) | 0.039 |
|
Clinical presentation (solitary brain lesion) |
9% | 11.1% | 1.25(0.2–7.5) | 0.8 |