Table 1.
Characteristics of reported cases of sintilimab-induced myocarditis in lung cancer patients.
| Author, year | Age/sex | PT/stage | ICI and Concomitant drugs | Onset of myocarditis | Clinical presentation | ADR | Diagnostic method | Cardiac biomarkers | ECG | Treatment |
|---|---|---|---|---|---|---|---|---|---|---|
| Lin Y et al., 2022 | 66/M | Ade/IV | TC + Sintilimab | 3 weeks after 1 cycle | Chest pain, shortness of breath | Myocarditis | ECG, UCG, CAG | TnI, CK, CK- MB, NT-proBNP↑ | V5 - V9 ST↑ | MP, IG |
| Chen X et al., 2024 | 33/F | Ade/IV | PC + Sintilimab | 2 days after 3 cycles | Shortness of breath, productive cough | Myocarditis | ECG, Chest CT | α - HBDH, cTn, CK-MB, NT-proBNP↑ | Tachycardia | MP, De |
| Bi H et al., 2021 | 68/M | SCC/Ⅲb | TC + Sintilimab | 6 days after 3 cycles | Productive cough, progressive dysphagia | Myocarditis | ECG, CAG | CK, CK-MB, hs-cTnl, BNP↑ | CRBBB, Ⅱ°AVB, diffuse ST segment depression | MP |
| Xing Q et al., 2020 | 68/M | Ade/NA | Sintilimab | 4 days after 2 cycles | Fatigue, myalgia, shortness of breath, progressive muscle weakness | Myocarditis, myositis, rhabdomyolysis | ECG, UCG | CPK, Myo, TnT, anti-AChR-Ab↑ | CRBBB, Ⅲ°AVB | MP, IG, Mestinon, PE, TPM |
| Xia J et al., 2024 | 66/M | Ade/IVb | PN + Sintilimab | 2 weeks after 2 cycles | Double eyelid ptosis, chest tightness | Myocarditis, hepatitis, pneumonia | ECG, UCG, CTA, Chest CT | CK-MB, Myo, ultra-TNI, NT-proBNP, AST, ALT↑ | CRBBB, LAH, LAD, ST-T changes | MP, IG |
| Hu Y et al., 2023 | 60/M | SCC/ⅠA3 | TC + Sintilimab | after 2 cycles | No symptoms | Myocarditis | CTA, ECG, UCG, CMR, Chest CT, myocardial biopsy | TnT, NT-proBNP↑ | Normal sinus rhythm | MP |
| Zhang Y et al., 2023 | 58/M | Ade/IVb | PC + Sintilimab | after 1cycle | No symptoms | Myocarditis, myasthenia gravis, myositis | ECG, UCG, CAG, MPI, CMR, EMG | hsTNI, CK, CK-MB, Myo↑ | Sinus rhythm, type A pre-excitation syndrome | MP |
| The present case report | 71/M | SCC/T4N3Mx | G + Sintilimab | 17 days after 1cycle | Shortness of breath, cough, yellow sputum, fatigue, bilateral knee pain | Myocarditis | ECG, UCG, CAG | BNP, CK-MB, ultra-Tnl, Myo↑ | Abnormal Q waves, ST-segment elevation | MP, IG |
PT, pathological types; ICI, immune checkpoint inhibitors; M, male; Ade, adenocarcinoma; ECG, electrocardiograph; UCG, ultrasonic cardiogram; CAG, coronary arteriography; CMR, cardiac magnetic resonance; F, female; CTA, computed tomography angiography; SCC, squamous cell carcinoma; IG, immunoglobulin; MP, methylprednisolone; CRBBB, complete right bundle branch block; AVB, atrioventricular block; LAH, left anterior hemiblock; LAD, left axis deviation; PE, plasma exchange; ST, sinus tachycardia; APB, atrial premature beats; AT, atrial tachycardia.