Table 3.

CIA+LPS co-exposure induced mediators not significantly affected by systemic clodronate liposome delivery.

	Vehicle Liposome & Sal+Sal	Vehicle Liposome & CIA+LPS	Clodronate Liposome & CIA+LPS
BALF
TNF-⍺, pg/ml	6.7 (5.0)	186 (91.9)###	74.5 (30.3)#
CXCL2, pg/ml	56.4 (27.0)	88.2 (48.4)	89.5 (48.4)
Lung tissue
IL-6	27.6 (18.4)	85.7 (46.2)##	31.3 (41.1)
TNF-⍺, pg/ml	0.4 (0.7)	51.6 (24.9)###	28.7 (20.7)##
CXCL2, pg/ml	55.5 (25.1)	619.4 (254.8)####	278.9 (175.3)#
CCL2, pg/ml	98 (39)	1422 (797)###	1098 (814)##
CCL7, pg/ml	28 (37)	1795 (1206)###	877 (679)##
Neutrophil Elastase, ng/ml	2.3 (2.6)	21.1 (10.8)###	12.3 (5.2)##
Fibronectin, ng/ml	62.4 (18.4)	201.7 (49)###	161.3 (62)##

Mean (SD), n=8 mice/group except n=7 mice/vehicle liposome & saline exposures for lung fibronectin, neutrophil elastase, and CXCL2.

#represent statistical significance versus vehicle liposome & saline exposures. ^####<0.0001; ^###0.0001 to 0.001; ^##0.001 to 0.1, ^#0.01 to.005.