Table 1.
Clinical features of CD20+ PTCL-NOS.
| Case | Age | Sex | Clinical presentation | B symptoms | ECOG | Stage | IPI score | BM involvement | LDH | Treatments and response | Follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 69 | Male | Abdominal distension, splenomegaly | Present | 1 | IV | 2 | Present (Bone marrow biopsy) | 215U/L | CHOPE×2(PR), Unclear | Alive, PFS:23m, OS:23m |
| 2 | 48 | Male | Splenomegaly | Absent | 0 | IV | 1 | Present (Bone marrow biopsy) | 184U/L | CHOP×1,CHOPE×3(SD),BV+CHPE×2(SD),Azacitidine+Chidamide,Azacitidine+Chidamide+BTZ+CTX(SD),BR(SD) | Alive, PFS:14m, OS:14m |
| 3 | 61 | Female | Chest distress, cough, mediastinal mass | Absent | 1 | IV | 1 | Present (PET/CT) | 240U/L | CHOPE×4(SD),GemoxD×2, Radiotherapy (PR),R-Gemox-D×4(PR),Azacitidine+Chidamide(PD) | Alive, PFS:14m, OS: 16m |
ECOG, Eastern Cooperative Oncology Group performance; IPI, International Prognostic Index; BM, bone marrow; LDH, lactic dehydrogenase; C, cyclophosphamide; H, doxorubicin; O, vincristine; P, prednisone E, etoposide; BV, brentuximab vedotin; BTZ, bortezomib; BR, bendamustine, rituximab; GemoxD, gemcitabine, oxaliplatin, dexamethasone; R, rituximab; PR, partial remission; SD, stable disease; PD, progressive disease; m, months.