Table 2.

Analysis 2 (tumour areas): Spearman’s rank correlation coefficients ρ of histological PSMA expression (H-Score) to SUV_mean or SUV_max in PSMA PET

	Variable 2	ρ	p value	95% confidence interval
All areas	SUVmean	0.39	< 0.001	[0.18, 0.56]
All areas	SUVmax	0.36	0.001	[0.15, 0.54]
Areas cohort I	SUVmean	0.37	0.01	[0.11, 0.62]
Areas cohort II	SUVmean	0.37	0.03	[0.04, 0.64]
Areas cohort I	SUVmax	0.30	0.05	[0.004, 0.55]
Areas cohort II	SUVmax	0.37	0.03	[0.04, 0.64]
Areas > 400 μm²	SUVmean	0.83	< 10−4	[0.57, 0.94]
Areas > 400 μm²	SUVmax	0.79	< 0.001	[0.47, 0.92]
Areas cohort I > 400 μm²	SUVmean	0.93	< 0.01	[0.58, 0.99]
Areas cohort II > 400 μm²	SUVmean	0.89	0.03	[0.26, 0.99]
Areas | GTV > 5 ml	SUVmean	0.41	< 0.01	[0.15, 0.62]
Areas | GTV > 5 ml	SUVmax	0.38	< 0.01	[0.11, 0.60]

The patients were divided in two cohorts based on the PSMA-PET tracer used: [⁶⁸Ga]Ga-PSMA-11 in cohort I and [¹⁸F]PSMA-1007 in cohort II. 16 out of 76 co-registered tumour areas had a histological area over 400 μm², 10 from cohort I and 6 from cohort II. 14 out of 32 patients had a GTV larger than 5 ml