TABLE 1.
Phenotypic and Functional Comparison of Macrophages from Different Tissues
| Characteristic | Elicited peritoneal macrophages | Alveolar macrophages | Kupffer cells | Blood-derived macrophages | Activated microglial cells |
|---|---|---|---|---|---|
| CD11b | high | low | high | minimal | minimal |
| CD14 | low | low | minimal | high | minimal |
| CD68 | high | high | high | high | high |
| FcγR | high | low | low | low | low |
| MHC-II | high | low | minimal | low | low |
| Ag presentation | high | low | low | yes | |
| Esterase | low | high | low | low | minimal |
| Phagocytosis | high | low | high | low | low |
| IFN-γ | high | low | low | yes | |
| TNF-α | high | high | low | yes | |
| IL-1 | high | low | low | yes | |
| IL-6 | high | low | low | yes | |
| MIP-1 | low | high | low | yes | |
| MCP-1 | high | low | low | yes | |
| IL-10 | high | ? | minimal | yes |
The functional activities of elicited macrophages, Kupffer cells, and alveolar cells are adapted from the review by Laskin et al. [2] and blood-derived macrophages and microglial cells, from the reviews by Guillemin and Brew [3] and Hanisch [21]. MHC, Major histocompatibility complex; Ag, antigen; MIP-1, macrophage-inflammatory protein-1; MCP-1, monocyte chemoattractant protein-1.