FIGURE A2.

Isocitrate dehydrogenase activity as a function of substrate and Ca²⁺ concentrations. (A) The rate of IDH is studied as a function of isocitrate and Ca²⁺ concentrations in the physiological range (see Eq. 16). The analysis was performed with the following parameter values: [NAD⁺] = 9.5 mM; [ADP]_m = 2.0 mM; mM; s⁻¹ and those described in Table 3. (B) The IDH dependence on NAD⁺ concentration is analyzed at different ADP concentrations with [ISOC] = 0.5 mM, and [Ca²⁺] = 0.5 μM. Otherwise the parameters used are as in A.