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Model for fork blockage and breakage in vivo. Replication is initiated at the unidirectional origin and the fork encounters a norfloxacin-stabilized cleavage complex, resulting in fork blockage. Once the fork is blocked, the cleavage complex can reverse in vivo, presumably allowing for direct fork restart. Alternatively, the blocked replication fork can be processed by in vivo fork breakage (at either the fixed branch or the active fork).
