Fig. 9.
Simulation of system 3 when parameters lie in Region III. (Upper) Treatment starts on day 1 and lasts 7 days for patients undergoing treatment. βF = 12.0 × log(2) before treatment and -0.8 during treatment for patients infected with the nonresistant strain. β- = 3.0 × log(2) before treatment and -2.0 during treatment, β+ = 3.0 × log(2) before and during treatment for patients infected with the resistant strain. γ = 0.00001, τ = 0.001, κ = 1010F. (Lower) λ = 5.0, ν = 0.05, η = 5.0 × 10-14, μN = 0.05, μR = 0.05, TF = 5.62 × 106< TV+ = 2.48 × 1011, TV- = 5.48 × 107, and R0 = 1.24 > 1. The population of patients infected only with the nonresistant strain is effectively eliminated, and patients infected with the resistant strain completely dominate. (S(t), IN(t), IR(t)) converges to the steady state (83,0,17).