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Knockdown of Pu.1 expression in CD34+ murine bone marrow cells enhances cell fate determination to pro-B cells. CD34+ marrow cells were transfected with control siRNA or Pu.1 siRNA and then cultured with mSCF or mGM-CSF plus mIL-3 for 72 h, before harvesting for FACS analysis. CD19, CD43, and CD45R expression was significantly induced in these bone marrow hematopoietic cells when they were treated by Pu.1 siRNA for 72 h. Data are the mean ± SD of three independent experiments.
