Fig. 1.

Correlation between variant effect scores from VEPs and DMS experiments. The Spearman’s correlation between all VEPs and every selected DMS dataset. VEPs are split into “population-based” and “clinical-trained” and “population-tuned” methods based on the usage of human clinical and population variants during training. DMS datasets are classified as “direct” if they directly measure the ability of the target protein to carry out one or more functions, with all others being classified as “indirect.” The VEP with the highest correlation is noted for every DMS dataset