Table 2.

Risk of cancer by demographics among individuals with anxiety disorder

Variable	Cancer
	Cases	PY	Incidence	CHR (95% CI)	AHR (95% CI)
All
Anxiety free	9572	1059057.9	0.90	ref	ref
Anxiety	2653	245448.99	1.08	1.21 (1.16–1.26)**	1.29 (1.23–1.35)**
Age (years)
< 30
Anxiety free	289	167366.51	0.17	ref	ref
Anxiety	102	39826.83	0.26	1.51 (1.20–1.89)**	1.41 (1.12–1.78)*
30–44
Anxiety free	1918	375589.81	0.51	ref	ref
Anxiety	585	88077.34	0.66	1.32 (1.20–1.45)**	1.28 (1.16–1.41)**
45–64
Anxiety free	4555	389938.09	1.17	ref	ref
Anxiety	1235	89075.67	1.39	1.20 (1.12–1.27)**	1.23 (1.15–1.31)**
≥ 65
Anxiety free	2810	126163.49	2.23	ref	ref
Anxiety	731	28469.15	2.57	1.15 (1.06–1.25)**	1.31 (1.21–1.43)**
Sex
Female
Anxiety free	5600	683948.86	0.82	ref	ref
Anxiety	1572	155886.93	1.01	1.25 (1.18–1.32)**	1.34 (1.26–1.42)**
Male
Anxiety free	3972	375109.04	1.06	ref	ref
Anxiety	1081	89562.06	1.21	1.14 (1.07–1.22)**	1.22 (1.14–1.31)**
CCI
< 3
Anxiety free	6752	829947.93	0.81	ref	ref
Anxiety	1391	138277.10	1.01	1.24 (1.17–1.31)**	1.41 (1.33–1.50)**
≥ 3
Anxiety free	2820	229109.97	1.23	ref	ref
Anxiety	1262	107171.89	1.18	0.98 (0.92–1.05)	1.11 (1.04–1.19)*
Urbanization level
Urban
Anxiety free	3788	440498.31	0.86	ref	ref
Anxiety	1114	101344.07	1.10	1.29 (1.21–1.38)**	1.36 (1.27–1.45)**
Suburban
Anxiety free	2022	211110.12	0.96	ref	ref
Anxiety	530	48352.11	1.10	1.16 (1.05–1.28)*	1.27 (1.15–1.40)**
Rural
Anxiety free	3762	407449.47	0.92	ref	ref
Anxiety	1009	95752.81	1.05	1.15 (1.08–1.24)**	1.22 (1.14–1.31)**

Incidence: incidence density (100 per person-years)

*: p <.05, **: p <.001, CHR: crude hazard ratio, AHR: adjusted hazard ratio controlling for age, sex, income, region, urbanization level, and CCI score, CCI: Charlson comorbidity index, CI: confidence interval, PY: person-years