Table 2.
Various pluronic-based formulations and their research applications in different types of cancers.
| Cancer type | Pluronic formulation | Loaded material |
|---|---|---|
| Breast | Gold nanoparticle-coated pluronic-b-poly(L-lysine) nanoparticles | PTX |
| Pluronic CuTz-1-O2@F127 | Cu(I) and O2 | |
| Pluronic-lipid nanovesicle hybrids (LPL) | PTX | |
| Hyaluronic acid (HA)-conjugated P123 and F127 pluronics | Thymoquinone (TQ) | |
| Combination of L61 and F127 pluronics | DOX | |
| Phenylboric acid (PBA)-modified F127 and doxorubicin-grafted P123 | DOX | |
| Pluronic P123 was modified with α-tocopherol succinate | DOX | |
| Pluronic F68 (PF68)-attached polyamidoamine (PAMAM) dendrimer conjugates | DOX | |
| Folate-conjugated chitosan-pluronic P123 nanogels | PTX and Curcumin | |
| Pluronic-chitosan-folate nanomicelles | Quantum dots (QD) and DOX | |
| Pluronic F127 (PF127) and pluronic F68 (PF68) micelles | Vorinostat | |
| Pluronic F127 (PF127)-folic acid (FA) conjugated micelles | Fisetin (FS) | |
| Plu-EDTA microgels | Curcumin | |
| F68 pluronic coated with RBC membrane | PTX | |
| Lung | PCL/pluronic F68 | Silibinin (SB) |
| Pluronic P105 with Vitamin E-d-α-tocopheryl polyethylene glycol succinate | Oleanolic acid (OA) | |
| Pluronic F127 and heparin | Cisplatin | |
| Pluronics P105 and F127 | DTX | |
| Biotin-targeted pluronics F127 and P123 | Niclosamide (NCL) | |
| Gastrointestinal | Pluronic P85 | 5-fluorouracil (5-Fu) |
| F127 pluronics along with electrospun fibrous meshes | Camptothecin (CPT) and Curcumin | |
| Chitosan and pluronic-123 micelles | Metformin hydrochloride (MF) | |
| Combination of P123 and F127 pluronics | SN-38 and Lonidamine (LND) | |
| Pluronic-coated all-in-one nanosponges (ANS) | Tetrandrine (TET), DOX and PTX | |
| Pluronic F-68 coated with salicylic acid-chitosan | Sorafenib | |
| Cubosomes composed of pluronic F-127 and pluronic F68 | DTX | |
| Pluronics F127 and F68 | Ormeloxifene | |
| Pluronics F68 and F127 | Gemcitabine (GEM) | |
| Pluronic P123 with MCM-41 mesoporous material | DOX | |
| F68 pluronics | DOX | |
| Prostate | Pluronic F127 along with lithocholic acid | Sorafenib |
| Pluronic F68 and pH-sensitive linkers | CTX | |
| Pluronic F127 with polyethylenimine (PEI) and gold particles | PTX | |
| Ovarian and Uterine | Folate (FA)-pluronic F127-PLGA and PLGA-F127-PLGA block copolymers | PTX |
| Pluronic polymer F108 and tocophersolan (TPGS) | DTX | |
| Pluronic F127 micelles | Genistein (Gen) and Curcumin | |
| Pluronic F127 | All-in-one Cas9 construct | |
| Skin | Pluronic F-127 (PL) hydrogels | Nitric oxide donor S-nitrosoglutathione (GSNO) and Copper oxide (CuO) |
| Gelatin and pluronic F127 | Antagonistic programmed cell death protein 1 ntibody (aPD-1) and Vemurafenib | |
| P123 and F127 pluronics | Redaporfin | |
| Brain | PCL and pluronic F68 covered with the membrane of cancer cells | Indocyanine green (ICG) |
∗PTX: Paclitaxel, DOX: Doxorubicin, DTX: Docetaxel, CTX: Cabazitaxel, PCL: Polycaprolactone. Data obtained from Refs. [[82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135]].