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. 2025 Apr 10;13:1543636. doi: 10.3389/fcell.2025.1543636

FIGURE 2.

FIGURE 2

(A) HE staining of myocardial tissue from control and DOX-treated groups. The DOX group exhibits disordered cell arrangement, widened muscle fiber gaps, and vacuole-like changes in the cytoplasm; (B) Masson’s trichrome staining of myocardial tissue from control and DOX-treated groups. The DOX group displays pronounced myocardial fibrosis with increased collagen fiber accumulation; (C) TUNEL staining of myocardial tissue from control and DOX-treated groups. The DOX group shows a significant increase in apoptotic myocardial cells.