Table 2.

Oncogenes and tumor suppressor genes regulate tumor Gln metabolism.

Classification	Name	Expression level	Targets/Mechanisms	References
oncogene	CEMIP, c-Myc	up	upregulating SLC1A5 expression	(65, 66)
	c-Myc	up	upregulating GLS, GS expression	(67)
Tumor suppressor gene	P53 Rb	down down	inhibiting GLS2 expression inhibiting SLC1A5 expression	(68) (69)