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. 2025 Apr 12;56:102390. doi: 10.1016/j.tranon.2025.102390

Fig. 4.

Fig 4

miR-889–3p reverses the tumor-promoting effects of circHIPK2 on LSCC cells. a: TU686 cells were transfected with sicircHIPK2 or co-transfected with sicircHIPK2 and miR-889–3p inhibitors. circHIPK2 and miR-889–3p expression was detected by qRT-PCR. b: TU686 cell was transfected with sicircHIPK2 or co-transfected with sicircHIPK2 and miR-889–3p inhibitor. Cell proliferation was determined by CCK8 assay. c, d: Colony formation assay was performed to evaluate the proliferative ability of TU686 cell transfected with sicircHIPK2 or co-transfected with sicircHIPK2 and miR-889–3p inhibitor. e, f: Effects of sicircHIPK2 and miR-889–3p inhibitor on the migration of TU686 cells was evaluated by Transwell migration assays. g, h: TU686 cells were transfected with sicircHIPK2 or co-transfected with sicircHIPK2 and miR-889–3p inhibitor. Cell wound healing time was determined. *P < 0.05, ⁎⁎P < 0.01,⁎⁎⁎P < 0.001.