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. 2025 Apr 24;16:3843. doi: 10.1038/s41467-025-59170-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — a 6mA is mostly found in linker regions. 6mA, and hence, MACs are frequent in nucleosome-free regions, as exemplified in this genome snapshot (scaffold 3:1062358-1068209). b 6mA frequency over linker and nucleosome regions. Both regions were scaled and divided into ten equal-sized bins. c 6mA and nucleosome dyads profiles with respect to TSS, including 0.5 kb upstream and downstream regions. d Methylated genes display a more consistent fixed distribution (left) than unmethylated genes (right). Normalized occupancy of nucleosome dyads was plotted in reference to TSS, including 1.5 kb flanking regions. A heatmap with the average normalized occupancy signal is also displayed below. Kolmogorov-Smirnov test (KS) was performed to evaluate differences between frequency distributions (P < 0.001) (n = 1732 genes and 1149 genes for methylated and unmethylated genes, respectively). Source data are provided as a Source Data file.