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. 2025 Apr 24;16:3843. doi: 10.1038/s41467-025-59170-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a Phylogenetic tree of representative eukaryotic species coupled with a matrix indicating the presence (filled box) or absence (empty box) of each MTA-70 protein. Species are classified into color-coded groups. Fungal phyla clades are ordered in the same descending order they appear in the tree. b Schematic representation of the MTA1c present in R. microsporus (top) and the domain composition of each protein (bottom). Charge distribution is displayed under the schematic representations. c The interaction between Mta1, Mta9, and P1 was analyzed in a yeast two-hybrid assay. Mta1 shows both weak (-WLH) and strong (-WLA) interactions with Mta9 and P1. d Genome browser view (scaffold_4:1865593-1878823) showing 6mA presence and P1 enrichment (computed as IP/Input ratio). e The methylation complex binds preferentially to 6mA-rich regions. P1 enrichment from ChIP-seq experiments (top) and DAP-seq (bottom) was computer over MACs (divided into 50 bins). f Methylated genes (6mA) show a greater enrichment of P1 downstream of the TSS than unmethylated genes (No 6mA). Source data are provided as a Source Data file.