Appendix 2—table 2. Unadjusted levels of plasma metabolites lactate, pyruvate, and citrate in UK Biobank participants and among the top 10% of glaucoma polygenic risk score (PRS).
| Total population | Top 10% PRS | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | Overall | No Glaucoma | Glaucoma | p-value | Overall | No Glaucoma | Glaucoma | p-value |
| Sample size | 117,698 | 113,040 | 4,658 | 11,770 | 10,077 | 1,693 | ||
| Lactate, mmol/l (median [IQR]) | 3.94 [3.24, 4.75] |
3.95 [3.24, 4.76] |
3.82 [3.17, 4.60] |
<0.001 | 3.94 [3.25, 4.75] |
3.96 [3.27, 4.78] |
3.79 [3.16, 4.58] |
<0.001 |
| Pyruvate, mmol/l (median [IQR]) | 0.080 [0.063, 0.10] |
0.080 [0.06, 0.10] |
0.0780 [0.06, 0.10] |
<0.001 | 0.080 [0.06, 0.10] |
0.080 [0.06, 0.10] |
0.077 [0.06, 0.09] |
<0.001 |
| Citrate, mmol/l (median [IQR]) | 0.065 [0.057, 0.074] |
0.065 [0.06, 0.07] |
0.065 [0.06, 0.07] |
0.51 | 0.065 [0.06, 0.07] |
0.06 [0.06, 0.07] |
0.07 [0.06, 0.07] |
0.87 |
Abbreviations IQR, interquartile range.