Table 4.

Risk of reaching disability milestones from disease onset in LO-NMOSD compared to EO-NMOSD.

	HR (95% CI)	Adjusted HR1 (95% CI)
From disease onset to
EDSS 4	3.54 (2.47-5.10)	2.64 (1.81-3.84)
EDSS 6	3.98 (2.47-6.43)	3.25 (1.95-5.43)
EDSS 8	5.79 (2.48-13.510)	3.52 (1.44-8.59)

¹Adjusted for sex, year of NMOSD disease onset, antibody status, immunotherapy (yes/no).

CI, confidence interval; EDSS, Expanded Disability Status Scale; EO, early onset; HR, Hazard Ratio; LO, late onset; NMOSD, Neuromyelitis optica spectrum disorder.