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. 2025 Apr 24;15:14329. doi: 10.1038/s41598-025-94549-2

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — GO terms for cellular component, biological processes and molecular functions using differentially expressed proteins from each cell line. Functional enrichment for cellular components, biological process and molecular functions from up- and down-regulated proteins in siKRAS condition in (A) HCT116 cells, (B) SW480 cells, (C) LS174T cells, (D) SW837 cells. Enrichment was calculated by − log(p-value). Positive values represent up-regulated and negative values represent down-regulated cellular components, biological processes or molecular functions. Only top 5 GO terms are represented in the graphs.