Table 3. IDSA Guidance 2021 – Severity of C. difficile infection [31].

Non-severe	Leukocytosis with a WCC less than 15×109 l−1 and a serum creatinine level <1.5 mg dl−1
Severe	Leukocytosis with a WCC greater than 15×109 per litre cells ml−1 or a serum creatinine level >1.5 mg dl−1
Fulminant	Hypotension or shock, ileus and megacolon