Table 5. ASID 2016 - Severity of C. difficile infection [33].

Non-severe	Absence of all features consistent with severe CDI.
Severe	Any of the following features if no other explanation can be provided: WBC count of >15 000 cells ml−1 or a rise in serum creatinine level >50% above baseline or core body temperature >38.5 °C. Rigours, haemodynamic instability, peritonitis or evidence of bowel perforation, ileus or toxic megacolon, elevated lactate level, albumin level <25 mg l−1, large intestine distension, colonic wall thickening, fat stranding, unexplained ascites (imaging) or pseudomembranous colitis on colonoscopy.
Severe-complicated (or fulminant)	An episode of CDI complicated by toxic megacolon, admission to intensive care for severe sepsis, requirement for surgery or death due to CDI.