Table 3.
The Pleiotropy analysis by MR-PRESSO global test.
| Exposure | Outcome | Raw | Outlier corrected | Global P | Number of outliers | Distortion P | |||
|---|---|---|---|---|---|---|---|---|---|
| OR (CI%) | P | OR (CI%) | P | ||||||
| Type 2 diabetes | Diffuse large B-cell lymphoma | 1.01 (0.89–1.14) | 0.9 | NA | NA | 0.721 | NA | NA | |
| Obesity | 1.08 (0.9–1.31) | 0.44 | NA | NA | 0.788 | NA | NA | ||
| Diabetic hypoglycemia | 0.91 (0.76–1.07) | 0.3 | NA | NA | 0.31 | NA | NA | ||
| Hyperlipidemia | 0.97 (0.86–1.08) | 0.58 | NA | NA | 0.151 | NA | NA | ||
| Hyperthyroidism | 1.01 (0.83–1.23) | 0.93 | NA | NA | 0.18 | NA | NA | ||
| Type 2 diabetes | Lymphoid leukaemia |
1.0001 (0.9998–1.0004) |
0.64 | NA | NA | 0.174 | NA | NA | |
| Obesity |
0.9999 (0.9996–1.0003) |
0.69 | NA | NA | 0.96 | NA | NA | ||
| Diabetic hypoglycemia |
1.0004 (1-1.0007) |
0.07 | NA | NA | 0.134 | NA | NA | ||
| Hyperlipidemia |
0.9999 (0.9998–1.0001) |
0.53 | NA | NA | 0.843 | NA | NA | ||
| Hyperthyroidism | 1.0002 (0.9998–1.0005) | 0.36 | NA | NA | 0.589 | NA | NA | ||
| Type 2 diabetes | Follicular lymphoma | 1.01 (0.83–1.23) | 0.92 | NA | NA | 0.741 | NA | NA | |
| Obesity | 0.8 (0.55–1.15) | 0.27 | NA | NA | 0.628 | NA | NA | ||
| Diabetic hypoglycemia | 1.13 (0.88–1.44) | 0.38 | NA | NA | 0.338 | NA | NA | ||
| Hyperlipidemia | 1.1 (0.95–1.26) | 0.22 | NA | NA | 0.538 | NA | NA | ||
| Hyperthyroidism | 0.95 (0.72–1.25) | 0.71 | NA | NA | 0.09 | NA | NA | ||
| Type 2 diabetes | Non-Hodgkin’s lymphoma | 1.01 (0.92–1.11) | 0.82 | NA | NA | 0.113 | NA | NA | |
| Obesity | 0.98 (0.8–1.2) | 0.88 | NA | NA | 0.266 | NA | NA | ||
| Diabetic hypoglycemia | 0.91 (0.82–1.02) | 0.17 | NA | NA | 0.111 | NA | NA | ||
| Hyperlipidemia | 1.06 (1.01–1.11) | 0.02 | NA | NA | 0.932 | NA | NA | ||
| Hyperthyroidism | 1.07 (0.81–1.4) | 0.65 | NA | NA | < 0.001 | NA | NA | ||
| Type 2 diabetes | Lymph node neoplasm | 0.92 (0.79–1.07) | 0.27 | NA | NA | 0.086 | NA | NA | |
| Obesity | 1.02 (0.75–1.39) | 0.9 | NA | NA | 0.372 | NA | NA | ||
| Diabetic hypoglycemia | 0.95 (0.84–1.06) | 0.4 | NA | NA | 0.752 | NA | NA | ||
| Hyperlipidemia | 1.04 (0.95–1.14) | 0.38 | NA | NA | 0.497 | NA | NA | ||
| Hyperthyroidism | 0.99 (0.9–1.09) | 0.87 | NA | NA | 0.916 | NA | NA | ||