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. 2025 Apr 19;17(8):1368. doi: 10.3390/cancers17081368
COPD Chronic obstructive pulmonary disease
CTCAE Common Terminology Criteria for Adverse Events
PICOS Population, Intervention, Comparison, Outcomes and Study framework for systematic reviews
SMD Standardized mean differences
OR Odds ratio
95% CI 95 percent confidence interval
RCTs Randomized controlled trials
Mo Morphine
Fent Fentanyl
HyMo Hydromorphone
Oxy Oxycodone
po Per oral
sc Subcutaneous administration
tm Transmucosal administration
Inhal Inhalation
SAEs Severe adverse reactions
NS Not specified
HTA Arterial hypertension
RR Respiratory rate
SaO2 Peripheral oxygen saturation
VAS Visual analog scale for dyspnea
CPOT Clinical pain observational tool
ECOG Eastern Cooperative Oncology Group
NRS Numeric rating scale
QoL Quality of life
KPS Karnofsky performance status
MEDD Morphine equivalent daily dose
DOME Daily oral morphine equivalent dose. Effective dose: Dose that reduced the intensity of dyspnea by at least 50%.
6MWT 6-min walk test
OTFC Oral transmucosal fentanyl citrate
FBT Fentanyl buccal tablet
FPNS Fentanyl pectin nasal spray