SCD |
Sickle cell disease |
HbS |
Sickle cell hemoglobin |
sRBCs |
Sickle cell red blood cells |
Hb |
Hemoglobin |
RBCs |
Red blood cells |
HBB |
β-globin |
glutamic acid |
Glu |
valine |
Val |
adult hemoglobin |
HbA |
ROS |
Free oxygen radicals |
HbF |
Fetal hemoglobin |
B-CAM-1/Lu |
Basal cell adhesion molecule-1/Lutheran |
IAP |
Integrin-associated protein |
ICAM-4 |
Intercellular adhesion molecule-4 |
VOC |
Vaso-occlusive crisis |
VCAM-1 |
Vascular cell adhesion molecules-1 |
RNS |
Reactive nitrogen species |
NADPH |
Nicotinamide-adenine dinucleotide phosphate |
XO |
Xanthine oxidase |
ADMA |
Asymmetric dimethylarginine |
NOS |
Nitric oxide synthase |
MetHb |
Methemoglobin |
BH4 |
Tetrahydrobiopterin |
Hp |
Haptoglobin |
TF |
Transferrin |
TFR1 |
Transferrin receptor 1 |
SLC11A2 |
Member 2 of the solute transporter family 11 |
LIPs |
Labile iron complexes |
FTH1 |
Ferritin heavy chain 1 |
FTL |
Ferritin light chain |
SLC40A1 |
Member 1 of the solute transporter family 40 |
NCOA4 |
Nuclear receptor 4 |
SLC25A37/mitoferrin-1 |
Solute transporter family 25 member 37 |
SLC25A28/mitoferrin-2 |
Solute transporter family 25 member 28 |
VDAC |
Voltage-dependent anion channels |
NTBI |
Non-transferrin-bound iron |
PUFAs |
Polyunsaturated fatty acids |
PUFAs-OOH |
Lipid peroxides |
HNE |
4-hydroxynonenal |
MDA |
Malondialdehyde |
LPCAT3 |
Lysophosphatidylcholine acyltransferase 3 |
LOX |
Lipoxygenases |
LOOH |
Lipid peroxides |
SLC7A11 |
Solute Carrier Family 7 Member 11 |
SLC3A2 |
Solute Carrier Family 3 Member 2 |
MBOAT1 |
PL lysophospholipid acyltransferase 1 |
Nrf2 |
Nuclear factor erythroid 2-related factor 2 |
FTH1 |
Ferritin heavy chain 1 |
NQO1 |
Quinone oxidoreductase 1 |
HO-1 |
Heme oxygenase-1 |
TSS |
Transulfuration pathway |
DMF |
Dimethyl fumarate |
CBS |
De novo cysteine synthesis |