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. 2025 Apr 2;18(4):519. doi: 10.3390/ph18040519
EPR Enhanced permeability and retention
ROS Reactive oxygen species
RT Radiotherapy
WHO World Health Organization
EBRT External beam radiation therapy
LINACs Linear particle accelerators
TRT Targeted radionuclide therapy
SOCs Standards of care
LET Linear energy transfer
BNCT Boron neutron capture therapy
OARs Organs at risk
TME Tumor microenvironment
SSBs Single-strand breaks
DSBs Double-strand breaks
PARP Poly-ADP ribose polymerase
NP Nanoparticle
AGuIX Activation and Guidance of Irradiation by X-ray
GMP Good manufacturing practice
MRI Magnetic resonance imaging
WBRT Whole brain radiation therapy
SE Signal enhancement
EES Extracellular extravascular space
% ID Percentage of the injected dose
SD Standard deviation
LIBS Laser-induced breakdown spectroscopy
ICP-MS Inductively coupled plasma mass spectrometry
ICP-OES Inductively coupled plasma optical emission spectrometry
TEM Transmission electron microscopy
FITC Fluorescein isothiocyanate
Cy5.5 Cyanine 5.5
EEA1 Early endosome antigen 1
AIF Apoptosis-inducing factor
LAMP-1 Lysosome-associated membrane protein 1
AF488 Alexa Fluor 488
IV Intravenous
NIST National Institute of Standards and Technology
DOTA 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
LQ Linear quadratic
SF Survival fraction
SER Sensitizing enhancement ratio
MC Monte Carlo
FFF Flattening filter free
RBE Relative biological effectiveness
LEM Local effect model
DEFs Dose enhancement factors
TDRA Theory of dual radiation action
DER Dose enhancement ratio
DCFDA 2′,7′-dichlorofluorescein diacetate
DHR123 Dihydrorhodamine 123
H2DCFDA or DCFH-DA 2′,7′-dichlorodihydrofluorescein diacetate
M-H2DCFDA 5-(and-6)-chloromethyl-H2DCFDA
mROS Mitochondrial ROS
cROS Cytosolic ROS
GSH Glutathione
SEM Standard error of the mean
ATM Ataxia–telangiectasia mutated
ATR Ataxia–telangiectasia and Rad3-related protein
DDR DNA damage response
HR Homologous recombination
NHEJ Non-homologous end-joining
IF Immunofluorescence
AGE Agarose gel electrophoresis
FM Fluorescence microscopy
cGAS Cyclic guanosine monophosphate–adenosine monophosphate synthase
IFN Interferon
STING Stimulatory interferon genes
IHC Immunohistochemistry
Unk Unknown
BRCA1 Breast cancer 1
FACS Fluorescence-activated cell sorting
PI Propidium iodide
ANOVA Analysis of variance
APC Allophycocyanin
7-AAD 7-Aminoactinomycin D
SPECT/CT Single-photon emission computed tomography/computed tomography
TUNEL Terminal deoxynucleotidyl transferase dUTP nick end labeling
H-SCORE Histochemistry score
LC3B Microtubule-associated protein 1 light chain 3B
BODIPY Boron-dipyrromethene
MDA Malondialdehyde
4-HNE 4-hydroxynonenal
NRF2 Nuclear factor erythroid 2-related factor 2
GPX4 Glutathione peroxidase 4
ns Non-significant
ICD Immunogenic cell death
DAMPs Damage-associated molecular patterns
HMGB1 High-mobility group box 1
CRT Calreticulin
DCs Dendritic cells
TAMs Tumor-associated macrophages
ICIs Immune checkpoint inhibitors
PD-1 Programmed cell death protein 1
NK Natural killer
PBMC Peripheral blood mononuclear cells
NOX2 NADPH oxidase 2
IRF5 Interferon regulatory factor 5
iNOS Inducible nitric oxide synthase
TOM20 Translocase of the outer mitochondrial membrane 20
AMPK Adenosine monophosphate activated protein kinase
AMPKT172* Activated protein kinase on threonine 172
Tregs Regulatory T cells
MDSCs Myeloid-derived suppressor cells
TDLNs Tumor-draining lymph nodes
PMA Phorbol-12-myristate 13-acetate
ROIs Regions of interest
scRNA-seq Single-cell RNA sequencing
IL Interleukin
Tf Transferrin