Table 1.

Endpoints included in the SPIRIT guidelines.

PROs	Midterm complications	Long-term complications
Health-related quality of life (IBDQ-36 + SF-36)	Bowel damage in CD (Lémann index at 12-24 months)	Dysplasia or cancer (at 5 years)
Disability (IBD disability index)	IBD-related surgery (colectomy, CD-related surgery, endoscopic balloon dilation, perianal surgery at 24-36 months)	Mortality (both IBD-related and non-IBD-related mortality at 5 years)
Fecal incontinence (Jorge and Wexner [Cleveland score] at 6-12 months)	IBD-related hospitalizations (number of hospitalizations + cumulative length of stay from 12 to 24 months)
	Disease extension in UC (macroscopic proximal disease extension from 2 to 5 years)
	EIM from 12 to 36 months
	Permanent stoma
	Short-bowel syndrome

Abbreviations: CD, Crohn’s disease; EIM, extraintestinal manifestations; IBD, inflammatory bowel disease; IBDQ, inflammatory bowel disease questionnaire; SF, short-form; UC, ulcerative colitis.