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. 2025 Apr 10;32:101754. doi: 10.1016/j.mtbio.2025.101754

Table 2.

Characteristics of various laser-based processes for HMN manufacturing.

Method Parameter (μm) HMN Materials Pros Cons Ref.
Laser Micromachining Shapes: cone, pyramid Nickel, Polyetheretherketone (PEEK), Stainless steel High precision, minimal thermal damage, applicable to various materials High cost, slow processing speed, complex process [88,90,91]
Heights: 250-1000
Hollow diameter: 40–100
Laser Writing Shapes: cone, cylinder, syringe, pyramid Polymethyl Methacrylate (PMMA), Negative PR (SU-8, IP-S), polymer precursor (E-shell 300),
UV sensitive hybrid material (US-S4)
Precise pattern formation, non-contact, high-speed processing capability Limitations in processing multi-layer structures, material selection, precision limitations [87,[92], [93], [94], [95], [96], [97]]
Heights: 100-2000
Hollow diameter: 15-200
Laser Drilling Shapes: cone, syringe, pyramid Stainless steel, polyethylene terephthalate (Mylar), polycarbonate (PC), polymethyl methacrylate (PMMA), polymer High-speed processing, micro hole creation capability, adjustable for various depths Thermal damage, uniformity issues, uneven roughness [[99], [100], [101], [102], [103], [104]]
Heights: 50-1700
Hollow diameter: 50-1054
Laser Cutting Shapes: cone, syringe, pyramid Negative PR (SU-8), Nickel, Hyaluronic acid Fast cutting, precise cutting capability Thermal damage, limited to thick/reflective materials [[106], [107], [108], [109], [110]]
Heights: 720–2000
Hollow diameter: 20-50