Table 1. NcRNAs positively or negatively regulate lung cancer development.

NcRNAs	Location	Mechanisms	Functions	Reference
MiR-224	NSCLC cells	Directly target the caspase-3 and caspase-7 3’UTR, down-regulate the expression of caspase-3 and caspase-7	Promote lung cancer cells proliferation and metastasis	[36]
MiR-20a	NSCLC cells	Directly target EGR2 3’UTR, down-regulate the expression of EGR2	Promote lung cancer cell proliferation, invasion, and metastasis	[37]
MiR-18a-5p	NSCLC cells	Directly target IRF2 3’UTR, down-regulate the expression of IRF2	Promote lung cancer cell proliferation, invasion, and metastasis	[38]
MiR-221-3p	NSCLC cells	Directly target p27 3’UTR, down-regulate the expression of p27	Promote cell cycle progression in lung cancer	[39]
MiR-210	NSCLC cells	Directly target LOXL4	Promote lung cancer cell proliferation, invasion, and metastasis	[40]
MiR-186-5p	NSCLC cells	Directly target PTEN	Promote lung cancer cell proliferation, invasion, and metastasis	[41]
MiR-143	NSCLC cells	Reduce CXCR4, Vimentin, MMP-1, Snail-1, c-Myc expression level, and increasing E-cadherin expression levels	Inhibit lung cancer cell proliferation, invasion, and metastasis	[42]
MiR-30c	NSCLC cells	Inhibit Epithelial-mesenchymal transition (EMT) through down-regulation of MTDH and HMGA2 expression, EMT mediates the development of malignant tumor metastasis	Inhibit lung cancer cell proliferation, invasion, and metastasis	[43,44]
MiR-30a-30p	NSCLC cells	Negatively regulate CNPY2 expression to inhibit EMT	Inhibit lung cancer cell proliferation, invasion, and metastasis	[45]
MiR-199a-5p	NSCLC cells	Down-regulate HIF-1α-STAT3 signaling pathway expression	Inhibit lung cancer cell proliferation, invasion, and metastasis	[46]
MiR-7	NSCLC cells	Directly target BCL-2 3’UTR, down-regulate the expression of BCL-2	Inhibit lung cancer cell proliferation, invasion, and metastasis	[47]
MiR-374a	NSCLC cells	Directly target TFGA 3’UTR, down-regulate the expression of TFGA	Inhibit lung cancer cell proliferation, invasion, and metastasis	[48]
MiR-590-5p	NSCLC cells	Directly target GAB1	Inhibit lung cancer cell proliferation, and invasion	[49]
MiR-141	SCLC cells	Directly target KLF12	Promote lung cancer cell angiogenesis	[50]
MiR-4739	NSCLC cells	Activation of Wnt/β-catenin pathway transduction	Promote lung cancer cell angiogenesis	[51]
MiR-497	NSCLC cells	Directly target Vascular Endothelial Growth factor-A(VEGF-A)	Inhibit lung cancer cell angiogenesis	[52]
MiR-199a-5p	NSCLC cells	Directly target SLC2A1	Inhibit lung cancer cell proliferation and glycolysis	[53]
LncR-LET	NSCLC cells	Inhibition of Notch signaling pathway by down-regulating Notch 1	Inhibition of lung cancer cell proliferation and malignancy	[54,55]
LncR-00115	NSCLC cells	Promote the expression of ITGB1 via sponging miR-607	Promote lung cancer cell proliferation, invasion, and metastasis	[56]
LncR-AC020978	NSCLC cells	Up-regulation of PKM2/HIF-1α axis expression	Promote lung cancer cell proliferation and glycolysis	[57]
LncR-FAM83A-AS1	NSCLC cells	Promotion of HIF-1α transcriptional activity directly	Promote lung cancer cell proliferation and glycolysis	[58]
LncR-MCM3AP-AS1	Lung cancer cells	Sponge miR-340-5p to down-regulate KPNA4 expression	Promote lung cancer cell angiogenesis	[59]
LncR-PANDAR	NSCLC cells	Up-regulation of BECN1 expression	Activation of autophagy in lung cancer cells	[60]
LncR-NBAT1	NSCLC cells	Inhibition of ATG7 transcriptional activity	Inhibit autophagy in lung cancer cells	[61]
LncR-01559	NSCLC cells	Sponge miR-1343-3p	Promote autophagy, proliferation and metastasis of lung cancer cells	[62]
LncR- FAM83A-AS1	NSCLC cells	Up-regulation of MET expression to inhibit AMPK activation	Inhibit autophagy and promote cells proliferation in lung cancer	[63]
CircR-GFRA1	NSCLC cells	Sponge miR-188-3p to activate the PI3K/AKT pathway	Promote lung cancer cells proliferation	[64]
CircR-WHSC1	NSCLC cells	Sponge miR-590-5p to up-regulate SOX5 expression	Promote lung cancer cells proliferation, invasion and metastasis	[65]
CircR-0001777	NSCLC cells	Sponge miR-942-5P to promote PRICKLE2 expression	Inhibit lung cancer cells proliferation, invasion and metastasis and glycolysis	[66]