Table 3.
(1:3 matching for categorical variables) univariate logistic regression analysis.
| Characteristics | β | SE | Wald | OR | 95%CI | P | |
|---|---|---|---|---|---|---|---|
| Lower limit | Upper | ||||||
| Female age (years) | |||||||
| Age <35 | 1 (reference) | ||||||
| Age ≥35 | −0.66 | 0.056 | −11.856 | 0.517 | 0.463 | 0.576 | <0.001 |
| BMI (kg/m2) | |||||||
| Underweight (<18.5) | 1 (reference) | ||||||
| Normal weight (18.5 ≤24.0) | 0.03 | 0.075 | 0.403 | 1.031 | 0.890 | 1.194 | 0.687 |
| Overweight (24.0 ≤28.0) | −0.024 | 0.051 | −0.483 | 0.976 | 0.884 | 1.078 | 0.629 |
| Obesity (≥28.0) | −0.099 | 0.09 | −1.104 | 0.905 | 0.759 | 1.080 | 0.270 |
| Gravidity (number of pregnancies) | −0.087 | 0.016 | −5.431 | 0.917 | 0.889 | 0.946 | <0.001 |
| Parity (number of births) | −0.354 | 0.05 | −7.035 | 0.702 | 0.636 | 0.774 | <0.001 |
| Infertility duration ≥10 years (%) | −0.276 | 0.097 | −2.847 | 0.758 | 0.626 | 0.917 | 0.004 |
| Infertile type | |||||||
| Primary infertility | 1 (reference) | ||||||
| Secondary infertility | −0.124 | 0.041 | −2.995 | 0.884 | 0.815 | 0.958 | 0.003 |
| Infertile factors | |||||||
| Tubal/pelvic factor | −0.382 | 0.054 | −7.145 | 0.682 | 0.614 | 0.757 | <0.001 |
| Polycystic ovary syndrome | −0.17 | 0.13 | −1.311 | 0.843 | 0.653 | 1.087 | 0.190 |
| Ovarian dysfunction | −0.644 | 0.186 | −3.46 | 0.525 | 0.362 | 0.752 | 0.001 |
| Insulin resistance | −0.647 | 0.707 | −0.916 | 0.523 | 0.110 | 1.985 | 0.360 |
| Advanced maternal age | −0.66 | 0.056 | −11.856 | 0.517 | 0.463 | 0.576 | <0.001 |
| Recurrent miscarriage | −0.126 | 0.34 | −0.371 | 0.882 | 0.447 | 1.716 | 0.711 |
| Recurrent IVF failure | −0.466 | 0.366 | −1.275 | 0.627 | 0.298 | 1.267 | 0.202 |
| Uterine pathology or structural abnormalities | −0.484 | 0.127 | −3.817 | 0.616 | 0.479 | 0.788 | <0.001 |
| Fertilization type | |||||||
| IVF | 1 (reference) | ||||||
| ICSI | −0.388 | 0.049 | −7.93 | 0.679 | 0.617 | 0.747 | <0.001 |
| AMH (μg/L) | |||||||
| AMH <1.1 | 1 (reference) | ||||||
| 1.1 ≤AMH <4 | 0.283 | 0.103 | 2.745 | 1.327 | 1.086 | 1.627 | 0.006 |
| AMH ≥4 | 0.626 | 0.101 | 6.21 | 1.870 | 1.537 | 2.282 | <0.001 |
| AFC(n) | |||||||
| AFC <5 | 1 (reference) | ||||||
| 5 ≤AFC <15 | 0.275 | 0.164 | 1.683 | 1.317 | 0.959 | 1.823 | 0.092 |
| AFC ≥15 | 0.571 | 0.161 | 3.549 | 1.771 | 1.296 | 2.439 | <0.001 |
| Basal E2 level (pg/ml) | −0.001 | 0.001 | −1.44 | 0.999 | 0.998 | 1.000 | 0.150 |
| Basal FSH level (IU/L) | 0.151 | 0.048 | 3.148 | 1.163 | 1.061 | 1.279 | 0.002 |
| Basal LH level (mIU/ml) | 0.033 | 0.007 | 4.792 | 1.033 | 1.020 | 1.047 | <0.001 |
| Basal P level (ng/ml) | −0.037 | 0.011 | −3.293 | 0.963 | 0.942 | 0.985 | 0.001 |
| Gn starting dose | |||||||
| Other dosage (%） | 1 (reference) | ||||||
| 150 IU (%) | 0.225 | 0.052 | 4.319 | 1.252 | 1.131 | 1.387 | <0.001 |
| 225 IU (%) | 0 | 0.051 | −0.007 | 1.000 | 0.905 | 1.105 | 0.994 |
| Recombinant FSH dose | 0 | 0 | −2.166 | 1.000 | 1.000 | 1.000 | 0.030 |
| Recombinant FSH duration | 0.008 | 0.01 | 0.872 | 1.008 | 0.990 | 1.028 | 0.383 |
| Recombinant LH dose | 0 | 0 | −0.614 | 1.000 | 0.999 | 1.001 | 0.539 |
| Recombinant LH duration | −0.02 | 0.03 | −0.663 | 0.980 | 0.925 | 1.039 | 0.507 |
| FSH total dose | 0 | 0 | −4.305 | 1.000 | 1.000 | 1.000 | <0.001 |
| LH total dose | 0 | 0 | −5.279 | 1.000 | 1.000 | 1.000 | <0.001 |
| HMG total dose | 0 | 0 | −5.254 | 1.000 | 1.000 | 1.000 | <0.001 |
| HMG duration | −0.039 | 0.008 | −4.8 | 0.962 | 0.947 | 0.977 | <0.001 |
| GnRH-A | |||||||
| Ganirelix | 1 (reference) | ||||||
| Cetrorelix | −0.086 | 0.048 | −1.813 | 0.917 | 0.836 | 1.007 | 0.070 |
| Ganirelix total dose | 0.061 | 0.035 | 1.732 | 1.063 | 0.992 | 1.139 | 0.083 |
| Ganirelix duration | 0.016 | 0.009 | 1.761 | 1.016 | 0.998 | 1.034 | 0.078 |
| Cetrorelix total dose | −0.061 | 0.038 | −1.617 | 0.941 | 0.874 | 1.013 | 0.106 |
| Cetrorelix duration | −0.016 | 0.009 | −1.66 | 0.985 | 0.967 | 1.003 | 0.097 |
| GnRH-a dose on trigger day | 1.02 | 0.235 | 4.342 | 2.772 | 1.750 | 4.394 | <0.001 |
| HCG dose on trigger day | 0 | 0 | −5.217 | 1.000 | 1.000 | 1.000 | <0.001 |
| E2 level on trigger day (pg/ml) | 0 | 0 | 7.128 | 1.000 | 1.000 | 1.000 | <0.001 |
| FSH level on trigger day (IU/L) | −0.019 | 0.004 | −4.35 | 0.981 | 0.973 | 0.990 | <0.001 |
| LH level on trigger day (mIU/ml) | −0.004 | 0.003 | −1.215 | 0.996 | 0.991 | 1.002 | 0.224 |
| P level on trigger day (ng/ml) | 0.141 | 0.026 | 5.497 | 1.151 | 1.095 | 1.211 | <0.001 |
| Trigger day LH ≧10 U/L | −0.063 | 0.081 | −0.771 | 0.939 | 0.800 | 1.101 | 0.441 |
| Trigger day LH/Gn Day LH ≥ 2 | −0.161 | 0.074 | −2.167 | 0.851 | 0.735 | 0.984 | 0.030 |
| Endometrial morphology on hCG day | |||||||
| A | 1 (reference) | ||||||
| B | 0.072 | 0.049 | 1.467 | 1.075 | 0.976 | 1.183 | 0.142 |
| C | −0.129 | 0.088 | −1.467 | 0.879 | 0.739 | 1.044 | 0.142 |
| ELSE | 0.003 | 0.079 | 0.038 | 1.003 | 0.858 | 1.172 | 0.969 |
| Endometrial thickness(mm) | 0.021 | 0.011 | 1.919 | 1.022 | 1.000 | 1.044 | 0.055 |
| Number of embryos for ET | |||||||
| 1 embryo | 1 (reference) | ||||||
| 2 embryo | 0.419 | 0.044 | 9.598 | 1.520 | 1.395 | 1.655 | <0.001 |
| Embryo stage | |||||||
| D3 | 1 (reference) | ||||||
| D5/D6 | 0.741 | 0.129 | 5.748 | 2.098 | 1.636 | 2.712 | <0.001 |
| D3 + D3 | 1.032 | 0.218 | 4.741 | 2.806 | 1.833 | 4.308 | <0.001 |
| D3 + D5/D6 | 0.791 | 0.126 | 6.257 | 2.205 | 1.728 | 2.837 | <0.001 |
| D5/D6 + D5/D6 | 1.331 | 0.125 | 10.652 | 3.784 | 2.973 | 4.855 | <0.001 |
| ELSE | −10.534 | 139.277 | −0.076 | 0.000 | 83,305.302 | 0.940 | |
| Male information | |||||||
| Male age | −0.037 | 0.004 | −8.884 | 0.964 | 0.956 | 0.972 | <0.001 |
| Abnormal semen analysis | −0.038 | 0.042 | −0.895 | 0.963 | 0.887 | 1.046 | 0.371 |
| DFI (%) | |||||||
| DFI <30 | 1 (reference) | ||||||
| DFI ≥30 | −0.121 | 0.075 | −1.607 | 0.886 | 0.765 | 1.027 | 0.108 |
| Degree of OHSS | |||||||
| NO OHSS | 1 (reference) | ||||||
| Mild | 0.454 | 0.913 | 0.498 | 1.575 | 0.261 | 11.965 | 0.619 |
| Moderate | 0.049 | 0.5 | 0.098 | 1.050 | 0.386 | 2.856 | 0.922 |
| Severe | 1.371 | 0.563 | 2.436 | 3.938 | 1.428 | 13.825 | 0.676 |
PSM, propensity score matching; BMI, body mass index; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection.; AMH, anti-Mullerian hormone; FSH, follicular stimulating hormone; LH, luteinizing hormone; AFC, antral follicle counting; HMG, human menopausal gonadotropin; D3, cleavage-stage embryo; D5/D6/ELSE, blastocyst; OHSS, ovarian hyperstimulation syndrome.
The bold P values indicate statistical significance in univariate regression analysis with “whether live birth occurred”.