Table 5.
Parameter estimates, standard error (SE), and p values for the general linear models fitted to the outcome measures (specified in the table) for the nociceptive tests.
| Response | Von frey threshold (grams) | PRoD threshold (newtons) | Neuropen response (0–3) | Response latency (seconds) | Response latency (seconds) | Response latency (seconds) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| von Frey | S.E. | p-value | Prod | S.E. | p-value | Neuro pen | S.E. | p-value | Heat | S.E. | p-value | Cold | S.E. | p-value | CTES | S.E. | p-value | |
| Constant | 135.56 | 15.08 | <0.001*** | 2.76 | 0.79 | <0.001*** | 1.27 | 0.15 | <0.001*** | 13.17 | 0.98 | <0.001*** | 31.43 | 7.22 | <0.001*** | 16.62 | 1.77 | <0.001*** |
| Stifle | 105.99 | 72.64 | 0.14 | 1.36 | 3.20 | 0.67 | −1.24 | 0.63 | 0.05* | −0.55 | 1.91 | 0.78 | 12.74 | 12.25 | 0.30 | – | – | – |
| Hip | 148.82 | 14.37 | <0.001*** | 1.89 | 0.52 | <0.001*** | −0.81 | 0.16 | <0.001*** | 0.43 | 0.47 | 0.37 | 7.16 | 2.74 | 0.009** | – | – | – |
| OA | – | – | – | −0.42 | 0.68 | 0.53 | – | – | – | – | – | – | – | – | – | −0.68 | 0.98 | 0.49 |
| OANSAID | – | – | – | −0.83 | 0.76 | 0.27 | – | – | – | – | – | – | – | – | – | −0.86 | 1.09 | 0.43 |
| Stimulus number | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | −0.26 | 0.12 | 0.04* |
| Weight | – | – | – | 0.06 | 0.03 | 0.015* | −0.02 | 0.005 | <0.001*** | 0.09 | 0.03 | 0.005** | 0.65 | 0.25 | 0.009** | 0.07 | 0.07 | 0.32 |
| Stifle.weight interaction | – | – | – | – | – | – | 0.021 | 0.021 | 0.31 | – | – | – | – | – | – | – | – | – |
| Hip.weight interaction | – | – | – | – | – | – | 0.014 | 0.006 | 0.013** | – | – | – | – | – | – | – | – | – |
| OA. Stifle interaction | – | – | – | −0.31 | 3.80 | 0.94 | – | – | – | – | – | – | – | – | – | – | – | – |
| OANSAID. Stifle interaction | – | – | – | −2.47 | 3.91 | 0.53 | – | – | – | – | – | – | – | – | – | – | – | – |
| OA.Hip interaction | – | – | – | 1.31 | 0.66 | 0.047* | – | – | – | – | – | – | – | – | – | – | – | – |
| OANSAID. Hip interaction | – | – | – | 1.38 | 0.74 | 0.06 | – | – | – | – | – | – | – | – | – | – | – | – |
| Nociceptive stimulus (as opposed to null) | – | – | – | – | – | – | – | – | – | −4.00 | 0.38 | <0.001*** | −10.58 | 1.59 | <0.001*** | −6.75 | 1.48 | <0.001*** |
| Stifle. nociceptive stimulus interaction | – | – | – | – | – | – | – | – | – | 1.76 | 1.73 | 0.31 | – | – | – | – | – | – |
| Hip. nociceptive stimulus interaction | – | – | – | – | – | – | – | – | – | 1.92 | 0.52 | <0.001** | – | – | – | – | – | – |
| OA. nociceptive stimulus interaction | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | −1.76 | 0.84 | 0.04* |
| OANSAID. nociceptive stimulus interaction | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | −1.29 | 0.93 | 0.17 |
For the categorical variables the reference category was control, and metatarsus was the reference site. – indicates variables were not significant and were dropped from the model.
*
p ≤ 0.05; **p ≤ 0.01; *** p ≤ 0.001. CTES is Canine Thermal Escape System.