Table 4.

Changes in Midazolam and 1′‐Hydroxymidazolam PK Parameters After Administration of Midazolam Alone or with Coadministration of Mavacamten in a Virtual Healthy Volunteer Population by CYP2C19 Phenotype

	Midazolam		1′‐Hydroxymidazolam
CYP2C19 Phenotype	AUC GMR a	Cmax GMR a	AUC GMR a	Cmax GMR a
PM	0.65	0.79	0.98	1.09
IM	0.69	0.82	0.96	1.05
NM	0.71	0.84	0.96	1.04
UM	0.69	0.81	0.96	1.05

AUC, area under the concentration‐time curve; C_max, maximum observed plasma concentration; CYP, cytochrome P450; GMR, geometric mean ratio; IM, intermediate metabolizer; NM, normal metabolizer; PK, pharmacokinetic; PM, poor metabolizer; UM, ultrarapid metabolizer.

^a The 90% CIs could not be calculated in Simcyp Simulator version 21.