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. 2025 Apr 28;15(5):e70323. doi: 10.1002/ctm2.70323

FIGURE 2.

FIGURE 2

Inhibition of cyclic GMP‒AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway alleviated obliterative bronchiolitis (OB). (A) Experiment workflow: recipient mice were intraperitoneally injected with cGAS inhibitor RU.521 to explore the role of the cGAS in OB. (B) Representative haematoxylin and eosin (H&E)‐stained sections of transplanted trachea collected on day 28 post‐transplant (left panel) and a statistical diagram (right panel) showing the degree of stenosis in tracheal allografts (n = 5 per group, mean  ± SD, two‐way ANOVA test). (C) Representative Masson staining sections of allografts obtained on day 28 (left panel) and statistical charts (right panel) illustrating collagen deposition (n = 5 per group, mean  ± SD, two‐way ANOVA test). (D) Experiment workflow: macrophage‐specific Sting1 knockout mice were generated to explore the role of the cGAS/STING pathway in OB. (E) Representative H&E‐stained sections of transplanted trachea collected on day 28 post‐transplant (left panel) and a statistical diagram (right panel) showing the degree of stenosis in tracheal allografts (n = 5 per group, mean  ± SD, two‐way ANOVA test). (F) Representative Masson staining sections of allografts obtained on day 28 (left panel) and statistical charts (right panel) illustrating collagen deposition (n = 5 per group, mean ± SD, two‐way ANOVA test).