Table 4.
Age-stratified immediate histopathological correlation among women with AGC cytology with and without concurrent squamous cell abnormalities.
| Group | Squamous lesions | Glandular lesions | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age, y | Total | HSIL+, No. (%) | p | SCC, No. (%) | p | AIS+/AEH+, No. (%) | p | AC, No. (%) | p | |
| AGC + Sq | 25-39 | 12 | 0 | 0.294 | 0 | NS | 4 (33.3%) | 0.403 | 2 (16.7%) | 0.191 |
| 40-65 | 25 | 1 (4.0%) | 0 | 5 (20.0%) | 4 (16.0%) | |||||
| >65 | 6 | 1 (16.7%) | 0 | 3 (50.0%) | 3 (50.0%) | |||||
| Total | 43 | 2 (4.7%) | 0 | 12 (27.9%) | 9 (20.9%) | |||||
| AGC-Alone | <25 | 4 | 0 | 1.000 | 0 | 0.910 | 1 (25.0%) | 0.002 | 1 (25.0%) | <0.0001 |
| 25-39 | 206 | 6 (2.9%) | 1 (0.5%) | 19 (9.2%) | 7 (3.4%) | |||||
| 40-65 | 477 | 14 (2.9%) | 4 (0.8%) | 57 (12.0%) | 46 (9.6%) | |||||
| >65 | 39 | 1 (2.6%) | 0 | 12 (30.8%) | 11 (28.2%) | |||||
| Total | 726 | 21 (2.9%) | 5 (0.7%) | 89 (12.3%) | 65 (9.0%) | |||||
| AGC | <25 | 4 | 0 | 0.791 | 0 | 0.909 | 1 (25.0%) | 0.000444 | 1 (25.0%) | <0.0001 |
| 25-39 | 218 | 6 (2.8%) | 1 (0.5%) | 23 (10.6%) | 9 (4.1%) | |||||
| 40-65 | 502 | 15 (3.0%) | 4 (0.8%) | 62 (12.4%) | 50 (10.0%) | |||||
| >65 | 45 | 2 (4.4%) | 0 | 15 (33.3%) | 14 (31.1%) | |||||
| Total | 769 | 23 (3.0%) | 5 (0.7%) | 101 (13.1%) | 74 (9.6%) | |||||
AC, adenocarcinoma; AEH, atypical endometrial hyperplasia; AGC, atypical glandular cell; AGC + Sq, atypical glandular cells with concurrent squamous cell abnormalities; AGC-alone, atypical glandular cells without concurrent squamous cell abnormalities; AIS, cervical adenocarcinoma in situ; hrHPV, high risk human papillomavirus; HSIL, high-grade squamous intraepithelial lesion; SCC, squamous cell carcinoma; NS, not significant.